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The 2014 study that got the anti-aging community interested in metformin [26:00]

Meanwhile, the antidepressant action of imipramine and venlafaxine involves suppression of nitric oxide synthesis (Krass et al., 2011)

(57) demonstrated that mtNOS1 suppresses cisplatin-induced mitochondrial superoxide accumulation and apoptosis in colon cancer cells by enhancing SIRT3 activity, which stabilizes SOD2a key antioxidant enzyme